Version 2.0

Database Object View



SWISSPROT:HEM4_YEAST

ID   HEM4_YEAST     STANDARD;      PRT;   275 AA.
AC   P06174;
DT   01-JAN-1988 (REL. 06, CREATED)
DT   01-OCT-1996 (REL. 34, LAST SEQUENCE UPDATE)
DT   01-OCT-1996 (REL. 34, LAST ANNOTATION UPDATE)
DE   UROPORPHYRINOGEN-III SYNTHASE (EC 4.2.1.75) (UROS) (UROPORPHYRINOGEN-
DE   III COSYNTHETASE) (HYDROXYMETHYLBILANE HYDROLYASE (CYCLIZING))
DE   (UROIIIS).
GN   HEM4 OR ORF1 OR YOR278W OR O5463.
OS   SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
OC   EUKARYOTA; FUNGI; ASCOMYCOTINA; HEMIASCOMYCETES.
RN   [1]
RP   SEQUENCE FROM N.A.
RC   STRAIN=ATCC 28583 / FL100;
RX   MEDLINE; 88194672.
RA   LANGGUT W., ENTRUP R., SCHWEIZER E.;
RL   CURR. GENET. 11:177-184(1986).
RN   [2]
RP   SEQUENCE FROM N.A.
RC   STRAIN=S288C;
RA   CHERET G., BERNARDI A., SOR F.J.;
RL   YEAST 12:1059-1064(1996).
RN   [3]
RP   CHARACTERIZATION.
RX   MEDLINE; 95321013.
RA   AMILLET J.M., LABBE-BOIS R.;
RL   YEAST 11:419-424(1995).
CC   -!- FUNCTION: INVOLVED IN MITOCHONDRIAL IMPORT OF CYTOPLASMICALLY
CC       SYNTHESIZED PRECURSOR PROTEINS.
CC   -!- CATALYTIC ACTIVITY: HYDROXYMETHYLBILANE = UROPORPHYRINOGEN-III
CC       + H(2)O.
CC   -!- PATHWAY: FOURTH STEP IN PORPHYRIN BIOSYNTHESIS BY THE SHEMIN
CC       PATHWAY. INVOLVED IN HEME BIOSYNTHESIS.
CC   -!- CAUTION: WAS ORIGINALLY (REF.1) THOUGHT TO BE INVOLVED IN
CC       MITOCHONDRIAL IMPORT.
DR   EMBL; X04694; G4085; -.
DR   EMBL; X89633; E189403; -.
DR   PIR; S05883; RGBY7K.
DR   SGD; L0002903; HEM4.
KW   PORPHYRIN BIOSYNTHESIS; HEME BIOSYNTHESIS; LYASE.
FT   CONFLICT    231    275       HLRVASIGPTTKKYLDDNDVTSDVVSPKPDPKSLLDAIELY
FT                                QRHK -> IYGLRHRTYH (IN REF. 1).
SQ   SEQUENCE   275 AA;  30911 MW;  66F4292D CRC32;
>HEM4_YEAST
MSSRKKVRVLLLKNKTVPIDKYELECRSKAFEPIFVPLIKHTHVIQDFRNVLNTIPNYLN
TINYIIITSQRTVESLNEAIIPTLTSEQKAALLSKTVYTVGPATANFIRRSGFINVKGGE
DAGNGSILADIIIDDLSTDIKACPPSELLFLVGEIRRDIIPKKLHSKGIKVREVVTYKTE
ELSDGFKRFIHAMKECDEDEVFSDWVVVFSPQGTKEITQYLGDSNRLPGSHLRVASIGPT
TKKYLDDNDVTSDVVSPKPDPKSLLDAIELYQRHK

SWISSPROT:HEM4_SYNP7

ID   HEM4_SYNP7     STANDARD;      PRT;   264 AA.
AC   P42452;
DT   01-NOV-1995 (REL. 32, CREATED)
DT   01-NOV-1995 (REL. 32, LAST SEQUENCE UPDATE)
DT   01-NOV-1995 (REL. 32, LAST ANNOTATION UPDATE)
DE   UROPORPHYRINOGEN-III SYNTHASE (EC 4.2.1.75) (UROS) (UROPORPHYRINOGEN-
DE   III COSYNTHETASE) (HYDROXYMETHYLBILANE HYDROLYASE (CYCLIZING)).
GN   HEMD.
OS   SYNECHOCOCCUS SP. (STRAIN PCC 7942) (ANACYSTIS NIDULANS R2).
OC   PROKARYOTA; GRACILICUTES; OXYPHOTOBACTERIA;
OC   CYANOBACTERIA (BLUE-GREEN ALGAE); CHROOCOCCALES.
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 94169298.
RA   JONES M.C., JENKINS J.M., SMITH A.G., HOWE C.J.;
RL   PLANT MOL. BIOL. 24:435-448(1994).
CC   -!- CATALYTIC ACTIVITY: HYDROXYMETHYLBILANE = UROPORPHYRINOGEN-III
CC       + H(2)O.
CC   -!- PATHWAY: FOURTH STEP IN PORPHYRIN BIOSYNTHESIS.
DR   EMBL; X70966; G471285; -.
KW   PORPHYRIN BIOSYNTHESIS; LYASE.
FT   ACT_SITE    146    146       POTENTIAL.
SQ   SEQUENCE   264 AA;  28196 MW;  D85E124A CRC32;
>HEM4_SYNP7
MAEQPLIGKTILTTRAAGQSSPFAAQLRAAGAAVIEMPTLEIGPPSSWLPLDEAIAAIAD
FDWLILASANAVEAVQQRLAAQQKSWSDVPCAIAVVGQKTAQVLAAQGGKADYIPPEFIA
ESLVEHFPQPVAGQRLLFPRVETGGREQITQALQSQGAIVVEVPAYESRCPSQIPDDALI
ALRQAHLNLISFTSSKTVRNFCQLMASNLGVDWSARISGVAIASIGPQTSITCQELLGRV
EVEAQEYTLDGLLLAIEQWARQTT

SWISSPROT:HEM4_PSEAE

ID   HEM4_PSEAE     STANDARD;      PRT;   251 AA.
AC   P48246;
DT   01-FEB-1996 (REL. 33, CREATED)
DT   01-FEB-1996 (REL. 33, LAST SEQUENCE UPDATE)
DT   01-OCT-1996 (REL. 34, LAST ANNOTATION UPDATE)
DE   UROPORPHYRINOGEN-III SYNTHASE (EC 4.2.1.75) (UROS) (UROPORPHYRINOGEN-
DE   III COSYNTHETASE) (HYDROXYMETHYLBILANE HYDROLYASE (CYCLIZING)).
GN   HEMD.
OS   PSEUDOMONAS AERUGINOSA.
OC   PROKARYOTA; GRACILICUTES; SCOTOBACTERIA; AEROBIC RODS AND COCCI;
OC   PSEUDOMONADACEAE.
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 94211207.
RA   MOHR C.D., SONSTEBY S.K., DERETIC V.;
RL   MOL. GEN. GENET. 242:177-184(1994).
CC   -!- CATALYTIC ACTIVITY: HYDROXYMETHYLBILANE = UROPORPHYRINOGEN-III
CC       + H(2)O.
CC   -!- PATHWAY: FOURTH STEP IN PORPHYRIN BIOSYNTHESIS.
DR   EMBL; M74844; G496215; -.
KW   PORPHYRIN BIOSYNTHESIS; LYASE.
FT   ACT_SITE    142    142       POTENTIAL.
SQ   SEQUENCE   251 AA;  27105 MW;  B842496C CRC32;
>HEM4_PSEAE
MSGWRLLLTRPDEECAALAASLGEAGVHSSSLPLLAIDPLEETPEQRTLMLDLDRYCAVV
VVSKPAARLGLERLDRYWPQPPQQTWCSVGAATAAILEAYGLDVTYPEQGDDSEALLALP
AFQDSLRVHDPKVLIMRGEGGREFLAERLRGQGVQVDYLPLYRRRAPDYPAGELLARVRA
ERLNGLVVSSGQGLPKSVSVGGSDWPEIGRLPLFVPSPRVAEMARELGAQRVIDCRGASA
PALLAALTSAA

SWISSPROT:HEM4_MOUSE

ID   HEM4_MOUSE     STANDARD;      PRT;   265 AA.
AC   P51163;
DT   01-OCT-1996 (REL. 34, CREATED)
DT   01-OCT-1996 (REL. 34, LAST SEQUENCE UPDATE)
DT   01-OCT-1996 (REL. 34, LAST ANNOTATION UPDATE)
DE   UROPORPHYRINOGEN-III SYNTHASE (EC 4.2.1.75) (UROS) (UROPORPHYRINOGEN-
DE   III COSYNTHETASE) (HYDROXYMETHYLBILANE HYDROLYASE (CYCLIZING))
DE   (UROIIIS).
GN   UROS.
OS   MUS MUSCULUS (MOUSE).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA;
OC   EUTHERIA; RODENTIA.
RN   [1]
RP   SEQUENCE FROM N.A.
RC   STRAIN=B6/CBAF1J; TISSUE=LIVER;
RX   MEDLINE; 95331792.
RA   XU W., KOZAK C.A., DESNICK R.J.;
RL   GENOMICS 26:556-562(1995).
RN   [2]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 95178849.
RA   BENSIDHOUM M., GED C.M., POIRIER C., GUENET J.L., DE VERNEUIL H.;
RL   MAMM. GENOME 5:728-730(1994).
CC   -!- CATALYTIC ACTIVITY: HYDROXYMETHYLBILANE = UROPORPHYRINOGEN-III
CC       + H(2)O.
CC   -!- PATHWAY: FOURTH STEP IN PORPHYRIN BIOSYNTHESIS BY THE SHEMIN
CC       PATHWAY. INVOLVED IN HEME BIOSYNTHESIS.
CC   -!- SUBUNIT: MONOMER (BY SIMILARITY).
DR   EMBL; U18867; G953228; -.
DR   EMBL; U16216; G1041679; -.
DR   EMBL; U04439; G506638; -.
KW   PORPHYRIN BIOSYNTHESIS; HEME BIOSYNTHESIS; LYASE.
SQ   SEQUENCE   265 AA;  28504 MW;  B888D2C2 CRC32;
>HEM4_MOUSE
MKVLLLKDAKEDDSGLDPYIQELRLCGLEATLIPVLSFEFMSLPSLSEKLSHPEGFGGLI
FTSPRAVEAVKLCLEKDNKTEAWEKSLKDRWNAKSVYVVGSATASLVNKIGLDAEGAGSG
NAEKLAEYICSKPSSELPLLFPCGTIKGDTLPKMLKDKGIPMESMHVYQTVPHPGIQGSL
KSYYEDQGIPASITFFSPSGLKYSLEYIQALSGSSFDQIKFIAIGPSTTRAMAAKGLPVS
CTAESPTPQALAAGIRNVLKPNHCC

SWISSPROT:HEM4_HUMAN

ID   HEM4_HUMAN     STANDARD;      PRT;   265 AA.
AC   P10746;
DT   01-JUL-1989 (REL. 11, CREATED)
DT   01-JUL-1989 (REL. 11, LAST SEQUENCE UPDATE)
DT   01-OCT-1996 (REL. 34, LAST ANNOTATION UPDATE)
DE   UROPORPHYRINOGEN-III SYNTHASE (EC 4.2.1.75) (UROS) (UROPORPHYRINOGEN-
DE   III COSYNTHETASE) (HYDROXYMETHYLBILANE HYDROLYASE (CYCLIZING))
DE   (UROIIIS).
GN   UROS.
OS   HOMO SAPIENS (HUMAN).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA;
OC   EUTHERIA; PRIMATES.
RN   [1]
RP   SEQUENCE FROM N.A., AND PARTIAL SEQUENCE.
RX   MEDLINE; 89017136.
RA   TSAI S.-F., BISHOP D.F., DESNICK R.J.;
RL   PROC. NATL. ACAD. SCI. U.S.A. 85:7049-7053(1988).
RN   [2]
RP   REVIEW ON VARIANTS.
RX   MEDLINE; 96271980.
RA   XU W., ASTRIN K.H., DESNICK R.J.;
RL   HUM. MUTAT. 7:187-192(1996).
RN   [3]
RP   VARIANTS CEP PHE-4; ARG-73 AND MET-228.
RX   MEDLINE; 92128898.
RA   BOULECHFAR S., DA SILVA V., DEYBACH J.-C., NORDMANN Y., GRANDCHAMP B.,
RA   DE VERNEUIL H.;
RL   HUM. GENET. 88:320-324(1992).
RN   [4]
RP   VARIANTS CEP LEU-53 AND ARG-73.
RX   MEDLINE; 90234854.
RA   DEYBACH J.-C., DE VERNEUIL H., BOULECHFAR S., GRANDCHAMP B.,
RA   NORDMANN Y.;
RL   BLOOD 75:1763-1765(1990).
RN   [5]
RP   VARIANTS CEP ALA-62; VAL-66; ARG-73 AND MET-228.
RX   MEDLINE; 92147890.
RA   WARNER C.A., YOO H.-W., ROBERTS A.G., DESNICK R.J.;
RL   J. CLIN. INVEST. 89:693-700(1992).
RN   [6]
RP   VARIANTS CEP CYS-19; PHE-82; ALA-99; VAL-104 AND SER-205.
RX   MEDLINE; 95164728.
RA   XU W., WARNER C.A., DESNICK R.J.;
RL   J. CLIN. INVEST. 95:905-912(1995).
RN   [7]
RP   VARIANT CEP PRO-212.
RX   MEDLINE; 96209895.
RA   TANIGAWA K., BENSIDHOUM M., TAKAMURA N., NAMBA H., YAMASHITA S.,
RA   DE VERNEUIL H., GED C.;
RL   HUM. GENET. 97:557-560(1996).
CC   -!- CATALYTIC ACTIVITY: HYDROXYMETHYLBILANE = UROPORPHYRINOGEN-III
CC       + H(2)O.
CC   -!- PATHWAY: FOURTH STEP IN PORPHYRIN BIOSYNTHESIS BY THE SHEMIN
CC       PATHWAY. INVOLVED IN HEME BIOSYNTHESIS.
CC   -!- SUBUNIT: MONOMER.
CC   -!- DISEASE: DEFECTS IN UROS ARE THE CAUSE OF CONGENITAL
CC       ERYTHROPOIETIC PORPHYRIA (CEP) (ALSO KNOWN AS GUENTHER'S DISEASE).
CC       THE MANIFESTATIONS OF CEP ARE HETEROGENEOUS, RANGING FROM
CC       NONIMMUNE HYDROPS FETALIS DUE TO SEVERE HEMOLYTIC ANEMIA IN UTERO
CC       TO MILDER, LATER ONSER FORMS, WHICH HAVE ONLY CUTANEOUS LESIONS IN
CC       ADULT LIFE. THE DEFIENCY IN UROS ACTIVITY RESULTS IN THE NON-
CC       ENZYMATIC CONVERSION OF HYDROXYMETHYLBILANE (HMB) INTO THE
CC       UROPORPHYRINOGEN-I ISOMER.
DR   EMBL; J03824; G337463; -.
DR   PIR; A40483; A40483.
DR   MIM; 263700; -.
KW   PORPHYRIN BIOSYNTHESIS; HEME BIOSYNTHESIS; LYASE;
KW   DISEASE MUTATION.
FT   ACT_SITE    148    148       POTENTIAL.
FT   VARIANT       4      4       L -> F (IN CEP).
FT   VARIANT      19     19       Y -> C (IN CEP).
FT   VARIANT      53     53       P -> L (IN CEP; NO DETECTABLE ACTIVITY;
FT                                SEVERE PHENOTYPE).
FT   VARIANT      62     62       T -> A (IN CEP; NO DETECTABLE ACTIVITY).
FT   VARIANT      66     66       A -> V (IN CEP; RESIDUAL ACTIVITY; MILD
FT                                PHENOTYPE).
FT   VARIANT      73     73       C -> R (IN CEP; NO DETECTABLE ACTIVITY;
FT                                SEVERE PHENOTYPE).
FT   VARIANT      82     82       V -> F (IN CEP; HIGH RESIDUAL ACTIVITY;
FT                                MILD PHENOTYPE).
FT   VARIANT      99     99       V -> A (IN CEP).
FT   VARIANT     104    104       A -> V (IN CEP; RESIDUAL ACTIVITY).
FT   VARIANT     212    212       S -> P (IN CEP; NO RESIDUAL ACTIVITY).
FT   VARIANT     225    225       G -> S (IN CEP).
FT   VARIANT     228    228       T -> M (IN CEP; NO DETECTABLE ACTIVITY).
SQ   SEQUENCE   265 AA;  28627 MW;  E60CA8D8 CRC32;
>HEM4_HUMAN
MKVLLLKDAKEDDCGQDPYIRELGLYGLEATLIPVLSFEFLSLPSFSEKLSHPEDYGGLI
FTSPRAVEAAELCLEQNNKTEVWERSLKEKWNAKSVYVVGNATASLVSKIGLDTEGETCG
NAEKLAEYICSRESSALPLLFPCGNLKREILPKALKDKGIAMESITVYQTVAHPGIQGNL
NSYYSQQGVPASITFFSPSGLTYSLKHIQELSGDNIDQIKFAAIGPTTARALAAQGLPVS
CTAESPTPQALATGIRKALQPHGCC

SWISSPROT:HEM4_ECOLI

ID   HEM4_ECOLI     STANDARD;      PRT;   246 AA.
AC   P09126;
DT   01-MAR-1989 (REL. 10, CREATED)
DT   01-MAR-1989 (REL. 10, LAST SEQUENCE UPDATE)
DT   01-NOV-1995 (REL. 32, LAST ANNOTATION UPDATE)
DE   UROPORPHYRINOGEN-III SYNTHASE (EC 4.2.1.75) (UROS) (UROPORPHYRINOGEN-
DE   III COSYNTHETASE) (HYDROXYMETHYLBILANE HYDROLYASE (CYCLIZING)).
GN   HEMD.
OS   ESCHERICHIA COLI.
OC   PROKARYOTA; GRACILICUTES; SCOTOBACTERIA; FACULTATIVELY ANAEROBIC RODS;
OC   ENTEROBACTERIACEAE.
RN   [1]
RP   SEQUENCE FROM N.A.
RC   STRAIN=K12 / CS520;
RX   MEDLINE; 89041586.
RA   ALEFOUNDER P.R., ABELL C., BATTERSBY A.R.;
RL   NUCLEIC ACIDS RES. 16:9871-9871(1988).
RN   [2]
RP   SEQUENCE FROM N.A.
RC   STRAIN=K12;
RX   MEDLINE; 88096587.
RA   JORDAN P.M., MGBEJE B.I.A., ALWAN A.F., THOMAS S.D.;
RL   NUCLEIC ACIDS RES. 15:10583-10583(1987).
RN   [3]
RP   SEQUENCE FROM N.A.
RC   STRAIN=K12;
RX   MEDLINE; 88134062.
RA   JORDAN P.M., MGBEJE B.I.A., THOMAS S.D., ALWAN A.F.;
RL   BIOCHEM. J. 249:613-616(1988).
RN   [4]
RP   SEQUENCE FROM N.A.
RC   STRAIN=K12 / MG1655;
RX   MEDLINE; 92358234.
RA   DANIELS D.L., PLUNKETT G. III, BURLAND V.D., BLATTNER F.R.;
RL   SCIENCE 257:771-778(1992).
CC   -!- CATALYTIC ACTIVITY: HYDROXYMETHYLBILANE = UROPORPHYRINOGEN-III
CC       + H(2)O.
CC   -!- PATHWAY: FOURTH STEP IN PORPHYRIN BIOSYNTHESIS.
CC   -!- SUBUNIT: MONOMER.
DR   EMBL; X12614; G41667; -.
DR   EMBL; Y00883; G41676; -.
DR   EMBL; M87049; G148203; -.
DR   PIR; S02227; S02227.
DR   PIR; S30694; S30694.
DR   ECOGENE; EG10430; HEMD.
KW   PORPHYRIN BIOSYNTHESIS; LYASE.
FT   ACT_SITE    138    138       POTENTIAL.
FT   CONFLICT    236    236       A -> R (IN REF. 2 AND 3).
SQ   SEQUENCE   246 AA;  27798 MW;  74167D35 CRC32;
>HEM4_ECOLI
MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS
QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE
LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT
MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA
LLRALQ

SWISSPROT:HEM4_BACSU

ID   HEM4_BACSU     STANDARD;      PRT;   262 AA.
AC   P21248;
DT   01-MAY-1991 (REL. 18, CREATED)
DT   01-JUL-1993 (REL. 26, LAST SEQUENCE UPDATE)
DT   01-NOV-1995 (REL. 32, LAST ANNOTATION UPDATE)
DE   UROPORPHYRINOGEN-III SYNTHASE (EC 4.2.1.75) (UROS) (UROPORPHYRINOGEN-
DE   III COSYNTHETASE) (HYDROXYMETHYLBILANE HYDROLYASE (CYCLIZING)).
GN   HEMD.
OS   BACILLUS SUBTILIS.
OC   PROKARYOTA; FIRMICUTES; ENDOSPORE-FORMING RODS AND COCCI; BACILLACEAE.
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 91193218.
RA   HANSSON M., RUTBERG L., SCHROEDER I., HEDERSTEDT L.;
RL   J. BACTERIOL. 173:2590-2599(1991).
RN   [2]
RP   SEQUENCE OF 1-130 FROM N.A.
RX   MEDLINE; 90236876.
RA   PETRICEK M., RUTBERG L., SCHROEDER I., HEDERSTEDT L.;
RL   J. BACTERIOL. 172:2250-2258(1990).
CC   -!- CATALYTIC ACTIVITY: HYDROXYMETHYLBILANE = UROPORPHYRINOGEN-III
CC       + H(2)O.
CC   -!- PATHWAY: FOURTH STEP IN PORPHYRIN BIOSYNTHESIS.
CC   -!- SUBUNIT: MONOMER (BY SIMILARITY).
DR   EMBL; M32130; -; NOT_ANNOTATED_CDS.
DR   EMBL; M57676; G143038; -.
DR   PIR; D35252; D35252.
DR   PIR; B42728; B42728.
DR   SUBTILIST; BG10343; HEMD.
KW   PORPHYRIN BIOSYNTHESIS; LYASE.
FT   ACT_SITE    146    146       POTENTIAL.
SQ   SEQUENCE   262 AA;  29114 MW;  F0AC476F CRC32;
>HEM4_BACSU
MENDFPLKGKTVLVTRNKAQAASFQQKVEALGGKAVLTSLITFRRALPNDVAEQVREDLA
APGWLVFTSVNGADFFFSYLKENQLILPAHKKIAAVGEKTARRLKMHNVSVDVMPQEYIA
EQLADALKQHAEPGETITVMKGNLSRDVIKQELVPLGFEVKEWVLYETIPDEEGIEALKD
AAGQYSFDYVTFTSSSTVHTFMHVLGEELKKWKANGTACISIGPLTNDALLTYGITSHTP
DTFTIDGMLELMCSMSREEERI

TREMBL:Q59683

ID   Q59683      PRELIMINARY;   PRT;   199 AA.
AC   Q59683;
DT   01-NOV-1996 (TREMBLREL. 01, CREATED)
DT   01-NOV-1996 (TREMBLREL. 01, LAST SEQUENCE UPDATE)
DT   01-NOV-1996 (TREMBLREL. 01, LAST ANNOTATION UPDATE)
DE   UROPORPHYRINOGEN III SYNTHASE (EC 4.2.1.75)
DE   (UROPORPHYRINOGEN-III SYNTHASE) (UROPORPHYRINOGEN-III COSYNTHETASE)
DE   (UROPORPHYRINOGEN-III COSYNTHASE) (HYDROXYMETHYLBILANE HYDROLYASE
DE   (CYCLIZING)).
GN   HEMD.
OS   PROTEUS MIRABILIS.
OC   PROKARYOTA; GRACILICUTES; SCOTOBACTERIA; FACULTATIVELY ANAEROBIC RODS;
OC   ENTEROBACTERIACEAE.
RN   [1]
RP   SEQUENCE FROM N.A.
RA   TROTOT P., SISMEIRO O., VIVAR S.C., GLASER P., DANCHIN A.;
RL   SUBMITTED (APR-1995) TO EMBL/GENBANK/DDBJ DATA BANKS.
CC   -!- CATALYTIC ACTIVITY: HYDROXYMETHYLBILANE =
CC       UROPORPHYRINOGEN-III + H(2)O.
DR   EMBL; U22969; G726358; -.
KW   LYASE.
SQ   SEQUENCE   199 AA;  22799 MW;  E6768384 CRC32;
>Q59683
MSILITRPSPAGEQLTQRLIDAGKHAFHAPLIEIAAGKELSILENKLNKLSTGDYLFLLS
KNAVWYANWQLNQLQQSWPDTLFYYGIGQSTAEEFQQLTAHSIRYPEFGETSEDLLALSS
LQQIENKRVLLLRGNGGRELLATTLRQRGAIVDECECYQRLFIDYVSEEFALKWKNAQVE
YLCGHQCEMLQQLLSSRWI

TREMBL:Q59335

ID   Q59335      PRELIMINARY;   PRT;   246 AA.
AC   Q59335;
DT   01-NOV-1996 (TREMBLREL. 01, CREATED)
DT   01-NOV-1996 (TREMBLREL. 01, LAST SEQUENCE UPDATE)
DT   01-NOV-1996 (TREMBLREL. 01, LAST ANNOTATION UPDATE)
DE   UROPORPHYRINOGENIII COSYNTHASE (EC 4.2.1.75)
DE   (UROPORPHYRINOGEN-III SYNTHASE) (UROPORPHYRINOGEN-III COSYNTHETASE)
DE   (UROPORPHYRINOGEN-III COSYNTHASE) (HYDROXYMETHYLBILANE HYDROLYASE
DE   (CYCLIZING)).
GN   HEMD.
OS   CHLOROBIUM VIBRIOFORME.
OC   PROKARYOTA; GRACILICUTES; ANOXYPHOTOBACTERIA; GREEN BACTERIA;
OC   CHLOROBIACEAE.
RN   [1]
RP   SEQUENCE FROM N.A.
RA   MAJUMDAR D., WYCHE J.H.;
RL   SUBMITTED (DEC-1992) TO EMBL/GENBANK/DDBJ DATA BANKS.
CC   -!- CATALYTIC ACTIVITY: HYDROXYMETHYLBILANE =
CC       UROPORPHYRINOGEN-III + H(2)O.
DR   EMBL; M96364; G144480; -.
KW   LYASE.
SQ   SEQUENCE   246 AA;  26786 MW;  68C2910D CRC32;
>Q59335
MKTVLVTRPKHQAAPFVRELEQYGLSTVVFPTIEIRPVAGWNVPDLTKFAGIFFTSPNSV
QFFLKHLLQTAPDELKNLQQTRVWAVGKTTGQDLEKHGVSIEPLPKIADAVNLMADIDPA
EIKGQTFLFVRGSLSLGTIPELIAEFGGTCVELTVYENLPPSLEDTQRVKDMLAEGKLDC
LSFTSPSTAKNFFEAIGSKELSDSVQIAAIGTTTSGALEKMGIKVDIIPEYFDGPSFAKA
IAEALK

TREMBL:Q59333

ID   Q59333      PRELIMINARY;   PRT;    60 AA.
AC   Q59333;
DT   01-NOV-1996 (TREMBLREL. 01, CREATED)
DT   01-NOV-1996 (TREMBLREL. 01, LAST SEQUENCE UPDATE)
DT   01-NOV-1996 (TREMBLREL. 01, LAST ANNOTATION UPDATE)
DE   UROPORPHYRINOGEN III SYNTHASE (EC 4.2.1.75)
DE   (UROPORPHYRINOGEN-III SYNTHASE) (UROPORPHYRINOGEN-III COSYNTHETASE)
DE   (UROPORPHYRINOGEN-III COSYNTHASE) (HYDROXYMETHYLBILANE HYDROLYASE
DE   (CYCLIZING)) (FRAGMENT).
GN   HEMD.
OS   CHLOROBIUM VIBRIOFORME.
OC   PROKARYOTA; GRACILICUTES; ANOXYPHOTOBACTERIA; GREEN BACTERIA;
OC   CHLOROBIACEAE.
RN   [1]
RP   SEQUENCE FROM N.A.
RC   STRAIN=F. THIOSULFATOPHILUM 8327;
RA   RHIE G., AVISSAR Y.J., BEALE S.I.;
RL   J. BIOL. CHEM. 271:8176-8182(1996).
CC   -!- CATALYTIC ACTIVITY: HYDROXYMETHYLBILANE =
CC       UROPORPHYRINOGEN-III + H(2)O.
DR   EMBL; U38348; G1033197; -.
KW   LYASE.
FT   NON_TER       1      1
SQ   SEQUENCE   60 AA;  6279 MW;  808AE254 CRC32;
>Q59333
STAKNFFEAIGSKELSDSVQIAAIGTTTSGALEKMGIKVDIIPEYFDGPSFAKAIAEALK

TREMBL:Q59294

ID   Q59294      PRELIMINARY;   PRT;   504 AA.
AC   Q59294;
DT   01-NOV-1996 (TREMBLREL. 01, CREATED)
DT   01-NOV-1996 (TREMBLREL. 01, LAST SEQUENCE UPDATE)
DT   01-NOV-1996 (TREMBLREL. 01, LAST ANNOTATION UPDATE)
DE   UROPORPHYRINOGEN-III SYNTHASE (EC 4.2.1.75)
DE   (UROPORPHYRINOGEN-III COSYNTHETASE) (UROPORPHYRINOGEN-III COSYNTHASE)
DE   (HYDROXYMETHYLBILANE HYDROLYASE (CYCLIZING)).
GN   HEMD.
OS   CLOSTRIDIUM JOSUI.
OC   PROKARYOTA; FIRMICUTES; ENDOSPORE-FORMING RODS AND COCCI; BACILLACEAE.
RN   [1]
RP   SEQUENCE FROM N.A.
RC   STRAIN=FERM P-9684;
RX   MEDLINE; 95394829.
RA   FUJINO E., FUJINO T., KARITA S., OHMIYA K.;
RL   J. BACTERIOL. 177:5169-5175(1995).
CC   -!- CATALYTIC ACTIVITY: HYDROXYMETHYLBILANE =
CC       UROPORPHYRINOGEN-III + H(2)O.
DR   EMBL; D28503; G460693; -.
KW   LYASE.
SQ   SEQUENCE   504 AA;  55210 MW;  E8349959 CRC32;
>Q59294
MEHGFVALVGAGPGDKGLITIRGAELLSQADVVVYDRLVSQEIIKMIPTTAEKIDVGKEN
KFHPVKQEEINHILLEKSLEGKKVIRLKGGDPFVFGRGGEELELLYENNIPFEVVPGVTS
AVAALCYGGIPATHRDFCSSLHIITGHAREGGQLSIPFHELKELNGTIVFLMGDSSLSYL
MNGLINAGMEKDMPAAIVENGTRPNQRKLVATVGTLEQKALEMEIKSPAIIAVGKVCSLS
EKFSWFMKKPLFGTKILVTRPKESSGTLVEKLRQLGAEPVEYPCIEVVPIPQNEKLYHAC
ENIREYGWILLTSKNGIQIFFDYLNSKGLDARVLANTKIGTVGSQTAKALKEVGLISDFT
PEIFDGRHLALGIAERVGENEKVLICDAAIASDDIVNILRSNNIKFDRVPLYNTNYINEN
SNKVKKSIVHGELKYITFTSASTVEGFIASMKDIPLESLTAVCIGNKTAEAAKKYNLRYV
VAEKSTIDSMIDKLLEIGGGNIYD

TREMBL:Q47250

ID   Q47250      PRELIMINARY;   PRT;   246 AA.
AC   Q47250;
DT   01-NOV-1996 (TREMBLREL. 01, CREATED)
DT   01-NOV-1996 (TREMBLREL. 01, LAST SEQUENCE UPDATE)
DT   01-NOV-1996 (TREMBLREL. 01, LAST ANNOTATION UPDATE)
DE   HEMD GENE ENCODING UROPORPHYRINOGEN-III COSYNTHETASE,
DE   COMPLETE CDS.
OS   ESCHERICHIA COLI.
OC   PROKARYOTA; GRACILICUTES; SCOTOBACTERIA; FACULTATIVELY ANAEROBIC RODS;
OC   ENTEROBACTERIACEAE.
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 87308012.
RA   SASARMAN A., NEPVEU A., ECHELARD Y., DYMETRYSZYN J., DROLET M.,
RA   GOYER C.;
RL   J. BACTERIOL. 169:4257-4262(1987).
DR   EMBL; M17360; G146336; -.
SQ   SEQUENCE   246 AA;  27768 MW;  2DE9E988 CRC32;
>Q47250
MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS
QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE
LQNIAGKRALILRGNGGRELIGDTLAARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT
MVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDA
LLRALQ
Copyright (C) 1997, Board of Trustees of the University of Illinois.